Mechanisms for TAM induction of neoplasms includes promoting tumor development by inducing interleukin 10 (IL-10) production in CRC cells through the STAT3 pathway, as well as upregulating production of cytokines such as vascular endothelial growth factor (VEGF) to induce tumor angiogenesis and tumor growth [46]. Here, VEGFA is linked to colorectal carcinoma.