EFNA3 and breast neoplasm: Moreover, the combination of at least two targets increased the detection of breast tumor samples, with 96% sensitivity and 99% specificity when combining LRRC15 and EFNA3; 96% sensitivity and 96% specificity for the combination of LRRC15 and TSPAN13; and 94% sensitivity and 95% specificity when combining LRRC15 and CA12 (Table 2).