For example, T-cell lymphoma, classic Hodgkin lymphoma, SM, AML, MPN, and certain solid tumors (e.g., lung cancer, renal cell carcinoma, etc.)can abnormally release IL-2, IL-3, IL-5 or GM-CSF [91,92,93,94,95]. The gene discussed is CSF2; the disease is acute myeloid leukemia.