TREM1 and cancer: Pathway analysis showed that the immune-high subtype was characterized by inhibition (negative Z-score) of six pathways associated with cytokine production and cell-mediated immune response (neuroinflammation signaling pathway, PD-1, PD-L1 cancer immunotherapy pathway, TREM1 signaling, pathogen-induced cytokine storm signaling pathway, role of pattern recognition receptors in recognition of bacteria and viruses, and Th1 pathway) (Figure 10E and Table S5).