Stimulators of angiogenesis, such as vascular endothelial growth factor (VEGF), promote immune evasion by inhibiting T cell function and DC maturation and contribute to the development of an immunosuppressive tumor microenvironment (TME) by increasing intratumoral Tregs and myeloid-derived suppressor cells (MDSCs) [53]. This evidence concerns the gene VEGFA and neoplasm.