KLK3 and posterior cortical atrophy: According to the CPG tool, and contrary to the D’Amico system, PCa patients may be subdivided into five groups—lrPCa, favorable intermediate-risk PCa (firPCa), unfavorable intermediate-risk PCa (uirPCa), hrPCa, and very high-risk PCa (vhrPCa)—again based on GS, serum PSA, and clinical stage [14].