TFE3 is a transcription factor that has been found in translocations in two different types of sarcomas, including alveolar soft part sarcoma (ASPS) and epithelioid hemangioendothelioma (EHE), as well as in perivascular epithelioid cell neoplasms (PEComa), which are neoplasms with uncertain malignant potential [182,183,184]. This evidence concerns the gene TFE3 and neoplasm with perivascular epithelioid cell differentiation.