PTEN and prostate cancer: Furthermore, our recent studies in a mouse model of premalignant high-risk prostate cancer (R26MTA; Pten+/f; Pb-Cre+) demonstrated that targeting the MTA1/PTEN/AKT signaling pathway by diets supplemented with natural stilbenes, such as pterostilbene and gnetin C (dimer resveratrol), was effective in preventing prostate cancer progression from high-grade PIN to adenocarcinoma [12,13].