Based on bioinformatic analyses of public datasets, we have previously demonstrated that high expression of the lysosomal protease CD is a predictor of good prognosis in NB patients bearing high levels of EGFR [7], and here, we show that NB patients with high expression of CTSD present with a better clinical outcome when combined with low rather than with high MYCN expression. This evidence concerns the gene CTSD and neuroblastoma.