In a meta-analysis of more than 3000 patients with breast cancer, de Nonneville et al. also found that NDRG1 was an independent predictor of overall survival in patients with ER+/HER2− breast cancer: tumors with high NDRG1 expression were associated with worse overall survival at 10 years compared with NDRG1-low tumors [60]. This evidence concerns the gene ESR1 and breast cancer.