KLK3 and posterior cortical atrophy: The newly developed PCa risk scores piRISK and PRISK demonstrated significantly improved performances compared to the PSA-based biomarkers tPSA and QfPSA, showing an increased diagnostic specificity and better indication for prostate biopsy, especially within the diagnostic grey area of tPSA in the range of 2 to 15 ng/mL (Figure 6 and Figure S3) [21,22,31].