Classical PCa risk factors (QfPSA and patient’s age) were combined with cfDNA-based parameters (cfDNA amount/mL and methylated RASSF1A, MIR129-2, NRIP3, and SOX8 copies/mL) to develop PCa risk scores PRISK1 and 2 with improved SEN and SPE. This evidence concerns the gene RASSF1 and posterior cortical atrophy.