KLK3 and Familial prostate cancer: Furthermore, two PSA-dependent prostate cancer risk scores were developed (PRISK1 and PRISK2) which combine known PCa risk factors QfPSA [56], patient’s age [30], and the amount of plasma cfDNA [55] with methylated RASSF1A, MIR129-2, NRIP3, and SOX8 cfDNA sequences/mL.