ZDHHC5 is transcriptionally upregulated in p53-mutant glioma, which mediates the palmitoylation of EZH2, affecting its methyl transferase activity, leading to lower levels of histone 3 lysine 27 trimethylation (H3K27me3), which contributes to malignancy and tumour progression [166]. This evidence concerns the gene TP53 and neoplasm.