In addition to the downregulation of key mediators of the MLL–menin complex such as HOXA9, MEIS1, PBX3, or CDK6, menin inhibition has been shown to reduce anti-apoptotic signaling molecules like B-cell lymphoma 2 (BCL-2) or fms-like tyrosine kinase 3 (FLT3) and induce differentiation in AML cells in vitro and in vivo [7]. Here, KMT2A is linked to acute myeloid leukemia.