Multiple immunological mechanisms have been proposed to elucidate the destruction of red blood cell precursors in RPCA, and one such mechanism similar to LGL neutropenia is the overproduction of TNF- α and IFN-γ, which can lead to the apoptosis of erythroid precursors in the BM, resulting in PRCA. The gene discussed is IFNG; the disease is Decreased total neutrophil count.