The current research has two primary objectives: firstly, to compare specific patterns of prostate cancer among firefighters and non-firefighters, including pertinent prognostic factors such as PSA levels, Gleason scores, treatment modalities, and the stage at diagnosis for the period 2004–2014; secondly, to assess prostate cancer-specific survival among firefighters in Florida (both career and volunteer) comparing them with the general population in Florida. The gene discussed is KLK3; the disease is prostate cancer.