SMARCA4 and adenocarcinoma: Notably, the frequency of the signet ring cell carcinoma, which is an unique subtype of adenocarcinoma, was significantly lower in the SMARCA4-mutated group than in the SMARCA4-normal group, with 3 cases (15.8%) versus 100 cases (42.2%); this difference was statistically significant (p = 0.044).