TF and central nervous system cancer: The Radscore had prognostic value and appeared to be linked to some of the key molecular alterations found in gliomas (IDH1 mutational status, genomic EGFR amplification, presence of tumor aneuploidy and chromosomal instability) in accordance with the important role played by TF in gliomagenesis, and the regulatory role played by some of these alterations in F3 expression [12,13,14,17].