Kline et al., in studies using cultures of stromal cells derived from the bone marrow of MM patients, showed that in addition to IL-6, IL-1β also induces an increase in the secretion of IL-8 (to the greatest extent), monocyte chemoattractant protein (MCP-1), and granulocyte-macrophage colony-stimulating factor (GM-CSF) [43]. This evidence concerns the gene CCL2 and Miyoshi myopathy.