CXCL8 and cancer: Moreover, it has been shown that proinflammatory cytokines, including IL-1β, IL-6, interleukin 8 (IL-8), and tumor necrosis factor-alpha (TNF-α), are involved in the breakdown of fat and muscle tissue, which indicates their potential diagnostic usefulness in predicting, diagnosing, and monitoring cancer cachexia [23,24].