According to the univariable analysis, the factors significantly correlated with higher risk of PFS reduction were male sex (HR = 1.70; p = 0.0402), higher stage of chronic kidney disease (>G2: HR = 2.42; p = 0.0004), anemia before treatment (HR = 2.21; p = 0.0385), low albumin level (HR = 2.69; p = 0.0001), and high level of creatinine (HR = 2.21; p = 0.0017). The gene discussed is ALB; the disease is chronic kidney disease.