The expressions of 12 sex-biased genes (COPG2, HDHD1A, INPP1, ITGA5, LCN6, MYO1A, RAET1L, RPS4X, TAGLN2, VAX2, ZRSR2, and ZYX) were increased in cancer tissue compared with normal thyroid tissue (Supplementary Table S2), and the expressions of 25 genes (ABHD10, ACRBP, ACTR3C, AGPAT3, AMELY, APITD1, CWH43, DDX3X, EIF1AX, EPHB2, IL12A, KDM6A, PCDH11Y, PIM1, PNPLA4, PPP1R2P9, PRKY, PTCD2, RBM46, SEPHS1, SYAP1, TRAM1L1, TXNDC15, ZNF396, and ZNF709) was decreased (Supplementary Table S3). The gene discussed is TXNDC15; the disease is cancer.