N-BPs enter monocytes, macrophages, the endothelium, and tumor cells to mediate their anti-cancer activity by blocking farnesyl pyrophosphate synthase (FPPS), a key enzyme in the mevalonate pathway involved in cholesterol synthesis, inducing phosphate antigens (pAg) such as isopentenyl pyrophosphate (IPP) accumulation and triggering Vδ2 T cells [24,25,26,27]. Here, FDPS is linked to cancer.