The TME is a complex ecosystem of cells and molecules that surround and intermingle with tumour cells interacting with immune elements, both adaptive (including CD8+ T cells, Th1 cells, Th2 cells, Th17 cells and B cells) and innate (including neutrophils, macrophages, and natural killer cells), fibroblasts, and the niche [35]. This evidence concerns the gene CD8A and neoplasm.