When predictors were studied in a univariate analysis, the authors observed that the GOLD score for COPD (HR 2.0, p = 0.003), IL-6 (HR 1.03, p = 0.007), IL-8 (HR 1.03, p = 0.022), and IL-10 (HR 1.35, p = 0.006) positively correlated with the incidence of irAEs, although in a multivariate analysis, only the GOLD score remained significantly associated with irAEs (HR 1.8, p = 0.037) [125]. The gene discussed is CXCL8; the disease is chronic obstructive pulmonary disease.