Rates of combined level 2 or 3 hypoglycemia were significantly higher for once-weekly insulin icodec rather than once-daily degludec: 19.93 events per PYE vs. 10.37 events per PYE, respectively (estimated rate ratio = 1.9; 95% CI: 1.5 to 2.3). Here, INS is linked to Hypoglycemia.