CACD (CACD1, GUCY2D, OMIM #600179: autosomal dominant; CACD2, PRPH2, OMIM 179605: autosomal dominant) presents with a well-demarcated area of atrophy of the RPE and choriocapillaris, usually centered in the macula [143,144,145]. The gene discussed is PRPH2; the disease is Atrophy.