Various CFTR variants related with fatty acid metabolism abnormalities have been reported in CF, such as an abnormally high arachidonic acid (AA) to docosahexaenoic acid (DHA) ratio and a linoleic acid (LA) deficiency, which is directly related to the severity of the CFTR variants [11,15,16,17]. This evidence concerns the gene CFTR and hyperinsulinemic hypoglycemia, familial, 4.