Frequent cytogenic rearrangements in pediatric AML patients are t (8;21) (q22;q22)/RUNX1-RUNX1T1 and inv (16) (p13q22)/CBFB-MYH11, which are associated with a good prognosis, and 11q23/KMT2A (MLL), which is associated with an intermediate or adverse prognosis, depending on the KMT2A partner gene involved [11,12]. This evidence concerns the gene RUNX1 and acute myeloid leukemia.