Regarding the secondary endpoints, a composite of renal failure requiring in-hospital CRRT and all-cause mortality, eGFR at the admission and the Mehran score were independent predictors at the univariable and multivariable analysis (OR: 0.95, 95% CI: 0.92–0.98, p < 0.001; OR: 1.28, 95% CI: 1.13–1.47, p < 0.001, respectively), whereas SGLT2-i assumption was confirmed as a protective factor (OR: 0.12, 95% CI: 0.03–0.40, p = 0.002) (Table 4). The gene discussed is SLC5A2; the disease is acute kidney injury.