In a prospective, open-label, cross-sectional study by Jobin et al. [91] involving 872 high-risk participants screened for colorectal cancer (CRC) using colonoscopy, it was deduced that individuals with diminished NK cell activity (median level of 86.0 pg IFNG/mL vs. 298.1 pg IFNG/mL, p = 0.0002) had a risk of CRC that was ten times greater than those with heightened NK cell activity (95% CI, 3.03–34.9). The gene discussed is IFNG; the disease is colorectal cancer.