On multivariate analysis including the main known risk factors for unfavorable progression of RA (i.e., number of baseline swollen joints, baseline CRP level, baseline ACPAs and RF, and modified Sharp score), FIB-4 score was not independently associated with evolution of DAS28-ESR over 2 years (Table 2) but was associated with baseline CRP level and number of swollen joints. Here, CRP is linked to rheumatoid arthritis.