Kidney fibrosis is attenuated under conditions of unilateral ureteral obstruction in mice with reduced MMP-2 production due to a deficiency in the MMP-2 inducer Basigin, and MMP-2 knockout in mice also results in reduced kidney fibrosis under conditions of unilateral ureteral obstruction [94,95]. This evidence concerns the gene MMP2 and Ureteral obstruction.