High-grade DCIS are usually estrogen receptor-negative (ER) and have higher amounts of copy number variations (CNVs), point mutations, aneuploidy, and cancer-related gene alterations, such as MYC, CCND1, ERBB2, TP53, and PIK3CA [29,31,32,33]. This evidence concerns the gene ERBB2 and ductal breast carcinoma in situ.