The Oncotype DX DCIS score was partly developed from the 21-gene Oncotype DX Recurrence Score in use for invasive tumours and includes five reference genes (ACTB, GAPDH, RPLPO, GUS, and TFRC) and seven genes relative to proliferation (KI-67, STK15, survivin, cyclin B1, MYBL2, PR, GSTM1). This evidence concerns the gene MKI67 and ductal breast carcinoma in situ.