Ricigliano and colleagues, in a study including both 3.0-T brain MRI and PET results, reported a 32% CPV increase and higher mitochondrial translocator protein (TSPO) expression in the plexus of asymptomatic individuals with radiologically isolated syndrome (RIS) compared with HCs, further supporting the argument that plexus enlargement and BCSFB dysfunction may be an early phenomenon in the disease course, far beyond the MS diagnosis [17,22]. This evidence concerns the gene TSPO and myeloid sarcoma.