In the same line, CP enlargement was found in individuals with RRMS but not in individuals with neuromyelitis optica spectrum disorder (NMOSD) or HCs, suggesting that CP/ TIV (choroid plexus/total intracranial volume) ratio increases may be specifically related to the inflammatory processes in MS, which includes the infiltration of peripheral activated T lymphocytes versus the antibody-mediated anti-AQP4 inflammation in NMOSD disorder [16,19]. This evidence concerns the gene CP and neuromyelitis optica.