In a 2009 study by A. Xanthis et al., reactive oxygen species (ROS) and CD36 expression were studied after siRNA inhibition of RAGE expression in monocytes from 10 T2D subjects and five matched controls: it was found that while AGEs increase oxidative stress and CD36 levels, this phenomenon is enhanced in subjects with T1D, where hyperglycemia is frequent and prolonged over time [42]. Here, CD36 is linked to type 1 diabetes mellitus.