PRRT2 and diabetic cardiomyopathy: Another mechanism by which hyperglycemia leads to diabetic cardiomyopathy is the hyperactivation of diacylglycerol (DAG)-protein kinase C (PKC), which leads to the increased synthesis of DAG, which in turn also induces alterations in arterial flow, extracellular matrix deposition, increased vasopermeability, and a general increase in the inflammation of myocardial tissue [40].