Therefore, in this study, potential coagulopathy (D-dimer, PT, and PTT) and inflammatory biomarkers (CRP and ferritin) have been delineated as readily available and inexpensive prognosticators/predictors of COVID-19 severity in the Qunfudhah population which could be used for early prediction of severity and timely initiation of appropriate therapy to avoid severe complications. The gene discussed is CRP; the disease is COVID-19.