Additionally, because of limited information and lack of heterogenic cohort studies and meta-analysis in Qunfudah, the diagnostic/prognostic suitability of coagulopathy markers, such as D-dimer as well as inflammatory biomarkers viz CRP and ferritin, in predicting disease COVID-19 severity has not been well determined yet in the population of Qunfudhah, Saudi Arabia. The gene discussed is CRP; the disease is blood coagulation disease.