Gene expression of signature astrocyte reactivity markers (Gfap, Lcn2, Steap4, Gbp2, Serping1, and Fbln5) were significantly upregulated in response to ocular hypertension at 2, 4, and 8 weeks compared to that in normotensive controls (Fig. 5E). This evidence concerns the gene LCN2 and ocular hypertension.