The pathways shared by the DEGs and DEMs mainly belonged to ABC transporters (glycine, L-alanine, L-glutamic acid, L-glutamine, L-histidine, L-isoleucine, L-lysine, L-phenylalanine, L-proline, L-threonine, L-valine, Leucine, maltotriose, ornithine, sucrose, taurine; ABCA12, ABCC2), protein digestion and absorption, mineral absorption, arginine and proline metabolism, shigellosis, pathways of neurodegeneration-multiple diseases, glutathione metabolism and the HIF-1 signaling pathway (Fig. 8D). Here, ABCC2 is linked to shigellosis.