The most common enrichment factors were related to central carbon metabolism in cancer (glycine, L-alanine, L-asparagine, L-glutamic acid, L-glutamine, L-histidine, L-isoleucine, L-methionine, L-phenylalanine, L-proline, L-valine, leucine, oxoglutaric acid, pyruvic acid), protein digestion and absorption, aminoacyl-tRNA biosynthesis, mineral absorption, D-amino acid metabolism, and ABC transporters, which may greatly contribute to the therapeutic efficacy of TCbHP treatment. Here, ABCG2 is linked to cancer.