ERBB2 and invasive breast carcinoma: However, in the last two decades, there have been many advances in HER2-targeted drugs, such as the monoclonal antibodies trastuzumab (H) and pertuzumab (P); tyrosine kinase inhibitors lapatinib, neratinib, tucatinib and pyrotinib; and the antibody-drug conjugates T-DM1 and trastuzumab deruxtecan (T-DXd), which have dramatically improved the outcomes of HER2 + BrCa patients [6].