We used the GSVA package in R software to analyze the head and neck squamous cell carcinoma (HNSCC) data from TCGA, and found that the expression of BMP2 was positively correlated with the PI3K-AKT pathway, angiogenesis, and EMT-markers (Fig. S10A, B, C). This evidence concerns the gene BMP2 and head and neck squamous cell carcinoma.