PIAS3 and neoplasm: Furthermore, the development of early myeloid-derived suppressor cells (eMDSCs) in BC was induced by tumor exosome-derived miR-9 and miR-181a, which activated the Janus kinase (JAK)/STAT signaling pathway by targeting suppressor of cytokine signaling-3 (SOCS3) and protein inhibitor of activated STAT-3 (PIAS3), respectively [131].