It has been shown that IL-1β-induced solute carrier family 7 member 11 (SLC7A11) overexpression upregulates PD-L1 and colony-stimulating factor 1 (CSF1) through the α-ketoglutarate/HIF1α axis, promoting MDSCs recruitment and infiltration in the hepatocellular carcinoma tumor niche [109]. The gene discussed is CD274; the disease is neoplasm.