Staudt and colleagues [14, 15] developed the LymphGen algorithm, and identified six genetic subtypes of DLBCL, including MCD (MYD88 L265P and CD79B co-mutated), BN2 (BCL6 fusions and NOTCH2 mutations), N1 (NOTCH1 mutations), EZB (EZH2 mutations and BCL2 translocations), ST2 (SGK1 and TET2 mutations), and A53 (TP53 mutations and deletions). Here, MYD88 is linked to diffuse large B-cell lymphoma.