HypoPP is the most frequent form of periodic paralysis in humans, with a prevalence rate of approximately 1 in 100,000 live births [2].About 60% of patients are classified as HypoPP-1 because they carry variants of the CACNA1S gene; while 20% patients are classified as HypoPP-2 with SCN4A gene variants [2]. The gene discussed is SCN4A; the disease is periodic paralysis.