PREX2 and colorectal carcinoma: In this context, an analysis of RNA-sequencing (RNA-seq) data comparing the IR-resistant cell line IR-SW480 with the IR-sensitive cell line SW480 led to the identification of a gene, phosphatidylinositol-3,4,5-triphosphate-dependent Rac exchange factor 2 (PREX2, also known as P-Rex2a), exhibiting high expression in IR-SW480 and a positive correlation with the radioresistance of CRC.