PROM1 and colorectal cancer: For CSC-specific targeted cytotoxic agents delivery, Ning et al. designed CD133 antibody conjugated nanoparticles to deliver SN-38, the active form of water-soluble camptothecin-11 (CD133Ab-NPs-SN-38) for CD133+ CSC targeting tested in HCT116 human colorectal cancer xenografts [109].