However, we found that both RF and anti-CCP antibodies were negative, without significantly extrathoracic symptoms related to autoimmune disease (other than limited joint pain) after the patient’s final visit, but positive results were obtained for anti-SSA, anti-Ro-52 and anti-dsDNA antibodies, and initial treatments with nintedanib and glucocorticoids were effective. The gene discussed is TRIM21; the disease is autoimmune disease.