ELP3 and septic shock: Compared to healthy control subjects, the concentrations of all measured circulating ECM degradation neo-epitopes in septic shock patients were increased: C1M (21.9 [19.7–24.3] vs 211.6 [151.7–274.0] ng/mL p < 0.001), C3M (6.6 [6.0–7.4] vs 18.0 [13.3–21.7] ng/mL p < 0.001), C4Ma3 (1.0 [1.0–1.2] vs 2.9 [2.1–3.4] ng/mL p < 0.001), C6M (10.8 [9.4–12.1] vs 35.5 [28.9–44.9] ng/mL p < 0.001), ELP-3 (16.5 [12.8–24.1] vs 90.8 [71.1–118.9] ng/mL p < 0.001) and X-FIB (9.1 [9.1–9.1] vs 484.7 [101.4–1786.9] ng/mL p < 0.001) (Fig. 2a–f).