REST and central nervous system cancer: We observed significantly elevated REST gene expression in both low- and high-grade glioma (p < 0.001), Fig. 1A. Consistent with other published analyses [6], higher REST expression was associated with worse overall survival in the pooled population of patients with low-grade glioma (LGG) and glioblastoma (logrank p = 9.9e − 11, Fig. 1B).