To analyze the impact of REST on GBM growth, we conducted a bioinformatics analysis of The Cancer Genome Atlas database (TCGA-GBM and TCGA-LGG projects) and compared REST mRNA abundance in low-grade glioma/LGG samples (n = 518) and GBM samples (n = 163) against normal brain samples (n = 207) from two combined datasets—TCGA and GTEx (Genotype-Tissue Expression project [15]). This evidence concerns the gene REST and central nervous system cancer.