We found that compared with those derived from normal hBMMSCs, exosomes derived from HPP patients’ hBMMSCs markedly reduced the proliferation, migration, and tube formation of ECs, and exosomes derived from HPP patients’ hBMMSCs with recovery of ALPL expression could rescue the angiogenic capacity of ECs compared with those from HPP hBMMSCs. This evidence concerns the gene ALPL and hypophosphatasia.