Additionally, both male and female patients showed significant variations in IL-17, MCP-1, OPN, and IFN-γ levels, which effectively differentiate between female patients with severe and non-severe infections Furthermore, according to the findings presented in Table 3, the expression level of the CB2 receptor in patients is significantly correlated with the levels of MOR (P = 0.0001), MCP-1 (P = 0.008), OPN (P = 0.042), and IFN-γ (P = 0.002). This evidence concerns the gene OPRM1 and infection.