The combination of receiver operating characteristic (ROC) curves, Kaplan-Meier analysis, and Cox regression analysis revealed that high expression of SLC7A11 was a prognostic risk factor for four different types of renal cancers, low expression of HMOX1 was a poor prognostic marker for patients, and increased expression of MT1G increased the prognostic risk for three additional classes of renal cancer patients, except for those with renal papillary cell carcinoma. The gene discussed is MT1G; the disease is renal carcinoma.