IGHG3 and myasthenia gravis: While PLEX seems to remove all subclasses to a similar extent [26], a recent study on PLEX in patients with MG showed that return to baseline autoantibody titres was fastest for AChR-IgG3, which had recovered at week 3, while AChR-IgG1 had reached 20% of baseline by that time (in line with the increased fractional turnover of IgG3 also in healthy individuals) [7].