ALPK2 and inflammatory bowel disease: However, ALPK2, over-expressed in human IBD and mostly in ulcerative colitis (Fig. 7f), was equally expressed in Maffl/flCd4Cre and double-deficient Prdm1fl/fMaffl/fCd4Cre mice (Fig. 7g), while CXCL10 was increased in both ulcerative colitis and Crohn’s disease (Fig. 7f), and was highest in the double-deficient LPLs (Fig. 7g).