Other genes identified within the human IBD ‘granulocyte, myeloid’ module, including NOD2, FCGR3 and PROK2, which were most highly expressed in the biopsies from ulcerative colitis (Fig. 7f), were most highly abundant in the Maffl/flCd4Cre mice (Fig. 7g). This evidence concerns the gene PROK2 and inflammatory bowel disease.