To identify the mechanism of metabolic alterations driven by TRAF6 loss in leukemia, we compared the upregulated genes in TRAF6-knockdown HEL cells (1.5-fold, P < 0.05) (Supplemental Table 1) with the 130 previously identified essential genes for AML cell survival in vitro and in vivo [32]. The gene discussed is TRAF6; the disease is leukemia.