TRAF6 and acute myeloid leukemia: To determine the molecular mechanism of the inhibitory effects of TRAF6 loss on leukemia function, we stratified AML patient samples based on TRAF6 expression and compared the gene expression profiles between AML with high (Z score >1.0, hereafter TRAF6hi AML) and low (Z score <1.0, hereafter TRAF6low AML) TRAF6 expression.